Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice
نویسندگان
چکیده
منابع مشابه
Deep brain stimulation alleviates parkinsonian
Authors: Alan D. Dorval, Alexis M. Kuncel, Merrill J. Birdno, Dennis A. Turner and Warren M. Grill 4 Affiliations: 1. Department of Biomedical Engineering, Duke University, Durham NC 5 2. Department of Neurobiology, Duke University Medical Center, Durham NC 6 3. Department of Surgery, Duke University Medical Center, Durham NC 7 4. Department of Bioengineering, University of Utah, Salt Lake City...
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The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette’s syndrome and major depression. This presentat...
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BACKGROUND Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. METHODS To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patien...
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The mechanism by which chronic, high frequency, electrical deep brain stimulation (HF-DBS) suppresses tremor in Parkinson's disease is unknown. Rest tremor in subjects with Parkinson's disease receiving HF-DBS was recorded continuously throughout switching the deep brain stimulator on (at an effective frequency) and off. These data suggest that the stimulation induces a qualitative change in th...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2019
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci122390